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Neurophysiological studies frequently reveal mixed axonal and demyelinating neuropathies (Li et al., 2016)
Additionally, there are indirect factors influencing TJs, such as matrix metalloproteinases (MMPs), NO, ROS, Rho-associated protein kinase (ROCK), and NF-B signaling pathways [120,121,122,123,124]
Another study has observed that ME1 could promote tumor growth, potentially through increasing NADPH production, which is required for GSH regeneration [103]
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